Derivation of a System-Independent Ki for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC50 Data
نویسندگان
چکیده
منابع مشابه
Derivation of a system-independent Ki for Pgp-mediated digoxin transport from system-dependent IC50 data by accounting for the contribution of additional digoxin transporters
متن کامل
Derivation of a system-independent Ki for Pgp-mediated digoxin transport from systemdependentIC50 data
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a study on construction of iranian life tables: the case study of modified brass logit system
چکیده ندارد.
15 صفحه اولInhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments].
BACKGROUND Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not fully understood. Digoxin is not extensively metabolized, but it is known to be transported by the drug efflux pump P-glycoprotein, which is expressed in excretory tissues (kidney, liver, intestine) and at the blood-brain barrier. Accordingly, we tested the hypothesi...
متن کاملInhibition of P-Glycoprotein–Mediated Drug Transport A Unifying Mechanism to Explain the Interaction Between Digoxin and Quinidine
Background—Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not fully understood. Digoxin is not extensively metabolized, but it is known to be transported by the drug efflux pump P-glycoprotein, which is expressed in excretory tissues (kidney, liver, intestine) and at the blood-brain barrier. Accordingly, we tested the hypothesi...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2018
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.117.075606